Home page
ENGLISH
Alphabetical index of skin diseases   Tuberous sclerosis complex
1
2
3
4
5
6
7
8
Tuberous sclerosis complex is a disorder  which affects certain internal organs and skin. 
Genetic mutations  of tumor suppressive genes (TSC1 and TSC2) are the cause of tuberous sclerosis.  The mutations result in loss of antitumor properties secondary to production of defective proteins (hamatrin, tuberin), which affects cell proliferation and size in various tissues (nervous system, skin, kidneys,  lungs, heart muscle). 
The diagnostic clinical criteria of this condition are well known and are based  on major and minor criteria.  
To the alphabetical index of skin diseases

Webmaster Dr. Dubin Israeli Board Certified dermatologist

© 2001

No parts of this site may be reproduced without a written permission